Taken from slashfilm:

“I like it in the Marvel comics when Spider-Man fights Morbius,” said Raimi. “He’s really cool. A vampire! I like that combination of superhero plus supernatural.”

This could be interesting, or it could be a bit of a letdown. Everyone’s seen the Underworld movies and Twilight which really aren’t that interesting. In the comics I always thought Morbius was more of a creation for Blade rather than Spider-Man. It would be interesting in that both characters used the same technology but different animals in their research.

Hopefully they finally have the Lizard in Spider-Man 4.